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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Semin Thromb Hemost. 2019 May 16;45(4):385–395. doi: 10.1055/s-0039-1687894

Figure 4.

Figure 4

Proposed mechanisms of tumor tissue factor (TF)-dependent metastasis. The full-length TF/factor (F)VIIa/FXa complex generates thrombin that activates platelets and generate fibrin. These activated platelets and fibrin inhibit the function of natural killer (NK) cells and attract monocytes/macrophage that helps establishment of premetastatic niche and tumor cell survival in metastatic niche. Cells and proteins were modified from Servier Medical Art, licensed under Creative Common Attribution 3.0 Unported License. (http://www.servier.fr/servier-medical-art)