Table 1.
Tissue factor expression regulators and pathways in human cancer
| Regulator | Pathway | Type of human cancer (cell line) | Refs |
|---|---|---|---|
| PI3K | PI3K/AKT/mTOR | glioma (23.11, U87MG) | 21, 23 |
| Akt | PI3K/AKT/mTOR | glioma (U87MG) | 23 |
| mTOR | PI3K/AKT/mTOR | glioma (23.11, U87MG), pancreatic (BON) | 21, 23, 35 |
| KRAS | RAS/MAP kinase | colorectal (379.2), colorectal and NSCLC primary tumor | 32, 33, 38 |
| Raf | RAS/MAP kinase | breast (MDA-MB-231) | 26 |
| MEK | RAS/MAP kinase | glioma (23.11), breast (MDA-MB-231) | 21, 26 |
| ERK | RAS/MAP kinase | glioma (U87MG), breast (MDA-MB-231) | 23, 26 |
| c-Met | MET receptor | brain (DAOY) | 22 |
| HGF | MET receptor | brain (DAOY) | 22 |
| Src | kinase | brain (DAOY) | 22 |
| EGF | EGFR family tyrosine kinase | breast (MDA-MB-468), endometrial (Ishikawa) | 29, 37 |
| TGFα | EGFR family tyrosine kinase | squamous cell carcinoma (A431) | 36 |
| EGFR | EGFR family tyrosine kinase | squamous cell carcinoma (A431), glioma (U87MG) | 23, 27, 36 |
| EGFRvIII | EGFR family tyrosine kinase | glioma (U373, U87MG) | 23, 36 |
| HER2 | EGFR family tyrosine kinase | breast (SKBR3) | 27 |
| KSR1 | EGFR family tyrosine kinase | squamous cell carcinoma (A431) | 27 |
| JNK1 | JNK pathway | glioma (U87MG) | 23 |
| AP-1 | transcription factor | glioma (U87MG), breast (MDA-MB-231) | 23, 26 |
| Egr-1 | transcription factor | glioma (U87MG), breast (MDA-MB-231, MDA-MB-435) | 23, 28 |
| NF-kB | transcription factor | glioma (U87MG), breast (MDA-MB-231) | 23, 26 |
| SP-1 | transcription factor | glioma (U87MG) | 23 |
| HIF-1α | transcription factor | breast (MDA-MB-231, MDA-MB-435) | 28 |
| p53 | transcription factor | colorectal (379.2) | 32, 33 |
| Snail | transcription factor | breast (MDA-MB-468) | 29 |
| ZEB1 | transcription factor | breast (MDA-MB-468) | 29 |
| PTEN | phosphatase | glioma (23.11, U87MG) | 21, 23 |
| IDH1 | metabolic enzyme | primary glioma | 24 |
PI3K: phosphatidylinositol-3 kinase; mTOR: mammalian target of rapamycin; HGF: hepatocyte growth factor; EGF: epidermal growth factor; TGFα: transforming growth factor alpha; EGFR: epidermal growth factor receptor; HER2: human epidermal growth factor receptor 2; KSR1: kinase suppressor of Ras 1; JNK1: c-Jun N-terminal kinase 1; AP-1: activator protein-1; Egr-1: early growth response protein-1; NF-κB: Nuclear factor-κB; HIF-1α: hypoxia induced factor-1α; PTEN: phosphatase and tensin homolog; IDH1: isocitrate dehydrogenase 1