Table 4.
Stratum-specific effect estimates for maternal diabetes and hypertensive disorders for three strata of maternal pre-pregnancy BMI in SEED
| Model / Strata | ASD vs. POP aOR (95% CI) | p-value for interaction | DD vs. POP aOR (95% CI) | p-value for interaction |
|---|---|---|---|---|
| Maternal Diabetes | ||||
| BMI: low, normal (<25 kg/m2)a | 0.95 [0.71, 1.27] | Reference | 1.23 [0.97, 1.57] | Reference |
| BMI: overweight (25-<30 kg/m2)a | 0.99 [0.71, 1.37] | 0.874 | 0.94 [0.69, 1.28] | 0.1833 |
| BMI: obese (≥30 kg/m2)a | 1.10 [0.80, 1.52] | 0.523 | 1.08 [0.79, 1.57] | 0.522 |
| Maternal Hypertensive Disorders | ||||
| BMI: low, normal (<25 kg/m2) b | 1.33 [1.06, 1.67] | Reference | 1.36 [1.10, 1.68] | Reference |
| BMI: overweight (25-<30 kg/m2)b | 1.23 [0.93, 1.64] | 0.687 | 1.31 [1.00, 1.72] | 0.840 |
| BMI: obese (≥30 kg/m2)b | 1.17 [0.89, 1.53] | 0.479 | 1.12 [0.86, 1.46] | 0.263 |
Adjusted for maternal age, race/ethnicity, maternal education, maternal smoking, and study site.
Adjusted for above (a.) plus plurality and parity.