Table 3.
Cerebrospinal fluid and MRI findings in RIS participants
| MRI findings | n (%) |
|---|---|
| Brain Gd-enhancing lesionsa | 8 (30%) |
| Infratentorial lesions | 11 (37%) |
| Juxtacortical lesions | 26 (87%) |
| Spinal cord lesionsb | 12 (40%) |
| CSFc | |
| Pleocytosis (≥5 WBC/mm3) | 3 (14%) |
| ≥2 CSF-specific oligoclonal bands | 16 (76%) |
| Elevated IgG index (≥0.8) | 6 (29%) |
| Elevated protein (≥45 mg/dL) | 4 (19%) |
| Any abnormal CSF finding (CSF pleocytosis and/or elevated IgG index and/or oligoclonal bands and/or elevated protein) | 18 (86%) |
a
Gadolinium contrast-enhanced brain MRI available for 27 RIS participants
b
Cervical spine MRI available for all RIS participants and thoracic spine MRI available for 24 participants
c
CSF analysis available for 21 RIS participants
MRI: magnetic resonance imaging; RIS: radiologically isolated syndrome; Gd: gadolinium; CSF: cerebrospinal fluid; WBC: white blood cells