Table 5.

Comparison of retinal layer thicknesses between RIS subjects with and without spinal cord or infratentorial lesions and HC

	Layer thicknesses mean (μm) (SD)			RIS with SC lesions vs. RIS without SC lesions		RIS with SC lesions vs. HC
Layer	RIS with SC lesions (n=20 eyes)	RIS without SC lesions (n=34 eyes)	HC (n=120 eyes)	Coefficient, (μm) (95% CI)	P-value	Coefficient, (μm) (95% CI)	P-value
p-RNFL	89.62 (11.25)	95.72 (9.54)	93.12 (10.15)	−3.70 (−10.28 to 2.87)	0.27	−2.07 (−8.22 to 4.09)	0.51
GCIP	71.70 (7.01)	77.44 (4.43)	76.97 (5.21)	−3.53 (−6.93 to −0.14)	0.041	−4.41 (−7.61 to −1.20)	0.007
	Layer thicknesses mean (μm) (SD)			RIS with IT lesions vs. RIS without IT lesions		RIS with IT lesions vs. HC
Layer	RIS with IT lesions (n=19 eyes)	RIS without IT lesions (n=35 eyes)	HC (n=120 eyes)	Coefficient, (μm) (95% CI)	P-value	Coefficient, (μm) (95% CI)	P-value
p-RNFL	89.33 (9.01)	95.89 (10.71)	93.12 (10.15)	−5.59 (−12.09 to 0.90)	0.09	−3.37 (−8.53 to 1.79)	0.20
GCIP	72.24 (3.85)	76.98 (6.54)	76.97 (5.21)	−3.49 (−6.62 to −0.35)	0.029	−4.07 (−6.33 to −1.82)	<0.001

RIS: radiologically isolated syndrome; HC: healthy controls; SC: spinal cord; SD: standard deviation; CI: confidence interval; p-RNFL: peri-papillary retinal nerve fiber layer; GCIP: ganglion cell + inner plexiform layer; IT: infratentorial