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. 2019 Feb 11;38(22):4412–4424. doi: 10.1038/s41388-019-0712-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Expression of pluripotency master regulators identifies aggressive cancers and disease resistance. a Immunohistochemical analysis of tissue microarrays for prostate cancer demonstrating frequency of OCT4, SOX2 and NANOG expression (left panel), illustrative tissue cores of prostate cancer stained for OCT4, SOX2 and NANOG (OSN) representative of high (OSN^hi) and low (OSN^lo) levels of expression (middle panel) and correlation of OSN sum score with disease-specific survival (DSS) by Kaplan–Meier analysis (right panel). b Same as a but for muscle-invasive bladder cancer (MIBC). c Same as b but for renal cancer. Note correlation of OSN sum score with Progression Free Survival (PFS) by Kaplan–Meier analysis (right panel)