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. 2019 Feb 11;38(22):4412–4424. doi: 10.1038/s41388-019-0712-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Pluripotent factors drive a core regulatory transcriptome in cancer. a Venn diagrams of genes demonstrating ≥2-fold up- and downregulation following culture in APSCE in prostate cancer cells (LNCaP and CWR22Rv1). The overlapping up- and downregulated genes in prostate cancer cells are noted. b Table of pathways most significantly altered following culture of prostate cancer cells (LNCaP and CWR22Rv1) in APSCE. c Heatmap demonstrating transcript expression of core regulatory signature in APSCE compared to culture in FM in prostate (LNCaP), bladder (RT112), renal (Caki-2), breast (MCF7), colon (HCT116) and lung (H661) cancer cells. Measurements made by real time PCR. Data represents at least three independent experiments and is Log2 transformed