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. 2019 Jun 3;9:8175. doi: 10.1038/s41598-019-44564-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Normalized Ca influx for closed state and open state binding of Kv blocking drug. (A) Normalized Ca currents at 5.3 and 5.6 mA/m² assuming no drug (black) or 200 μM (corresponding to 1 K_d concentration) on a closed-state binding model (red) and an openstate binding model (blue). (B) Normalized Ca integral at 5.1–6.0 mA/m² stimulation for 0–800 μM (corresponding to 0–4 K_d equivalents; K_d = 200 μM) drug concentration for the closed state and open state binding cases.