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. 2019 Jun 3;9:8251. doi: 10.1038/s41598-019-44698-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibitory neuron-specific inactivation of Hes1 leads to enhanced sociability and perseveration. (a) Crawley’s social interaction test. The number of contacts (Contact No), time spent in each compartment (Stay Time), distance traveled in each compartment (Distance), and number of entries into each compartment (Entry No) were recorded for wild-type control (n = 9) and Gad2-Cre;Hes1 cKO (n = 6) mice. Data are presented as mean ± SEM; *p < 0.05, **p < 0.01; two tailed Student’s t-test. (b) Barnes maze test. Probe tests were done on day 1 (Test 1) and day 8 (Test 2) after the training sessions. The number of visits to the correct hole (correctN) and wrong holes (wrongN), time spent in the correct hole (correctT) and wrong holes (wrongT), and total distance traveled (distance) were measured for wild-type control (black, n = 9) and Gad2-Cre;Hes1 cKO (gray, n = 6) mice. Data are presented as mean ± SEM; *p < 0.05; two tailed Student’s t-test.