FIGURE 1.

Dipotassium glycyrrhizinate (DPG) reduces cell viability and change morphology in glioblastoma cell lines. (A) DPG inhibits cell viability of U87MG cells treated with 12, 15, 18, 20, 24, and 28 mM DPG for 24, 48, and 72 h by MTT assay and the IC₅₀ was determined (18 mM for 48 and 72 h). (B) DPG inhibits cell viability of T98G cells treated with 20, 24, 28, and 32 mM DPG for 24, 48, and 72 h by MTT assay and the IC₅₀ was determined (24 mM for 48 and 72 h). (C) U87MG cell and nuclear morphological change were observed 48 and 72 h after DPG exposure. (D) T98G cell and nuclear morphological change were observed especially after 72 h of DPG exposure.