FIGURE 5.

Dipotassium glycyrrhizinate (DPG) decreases wound closure and inhibits cell migration in glioblastoma cell lines. (A) U87MG cell line treated with DPG fills the wound area (the area between the two dotted lines) more slowly than those untreated at 24, 48, and 72 h. (B) T98G cell line treated with DPG fills the wound area (the area between the two dotted lines) more slowly than those untreated at 24, 48, and 72 h. The wound-healing assay was expressed as relative wound width (24, 48, or 72 h average wound width divided by 0 h wound represented by the graphics). Graphics also shows average and standard deviation of three independent experiments. Statistics were performed in a two-tailed t-test with P ≤ 0.05.