Figure 7.
H. pylori colonization after oral therapeutic immunization. The H. pylori-infected Mongolian gerbils were orally immunized with FVpE plus PA, CTB-UE plus PA, CTB plus PA, FVpE, or PBS. (A) Quantitative culture of H. pylori. Number of live H. pylori per stomach was determined by quantitative culture. Data are mean ± S.D. *p < 0.05, ***p < 0.001. (B) H. pylori urease activity in the stomach. Urease tests were performed on gastric samples. Data are mean ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001. (C) Observation of H. pylori by IHC staining. H. pylori colonizing in the stomach were marked by black arrows.