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. 2019 May 28;10:1138. doi: 10.3389/fimmu.2019.01138

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Copyright © 2019 Guenther, Faisal, Uotila, Asens, Harjunpää, Savinko, Öhman, Yao, Moser, Morris, Tojkander and Fagerholm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition but not deletion of MRTF-A leads to altered CCR7 expression and no change in migration speed. (A) CD40 (B) CD80 (C) CD86 and (D) CRR7 expression in WT NT and MRTF-A inhibited dendritic cells (N = 6); (E) CCR7 expression of MRTF-A ⁻/⁻ and MRTF-A^+/+ (N = 5); surface marker expression was determined by flow cytometry. (F) CCR7 mRNA level of MRTF-A inhibited and NT WT dendritic cells determined by qPCR (N = 4). (G) Scatter plots of tracked WT NT and WT MRTF-A inhibited and (H) MRTF-A⁻/⁻ and MRTF-A^+/+ dendritic cell speeds in a 3D collagen matrix toward CCL19 are shown. Only cells faster than 1 μm/min have been evaluated as migratory and used for the analysis. *p < 0.05.