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. 2019 May 28;10:1133. doi: 10.3389/fimmu.2019.01133

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Copyright © 2019 Park, Son, Hwang, Ko, Lee, Doh and Jeon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A CACI-IMPACT platform and its working process. (a) Rail-based microstructures are embedded in microwells with 96 well plate format and the structures are integrated in a 2 × 6 rectangular array. Water tanks are allocated in both sides to maintain humidity in samples. (b) Schematic top and section view of a single well. The microstructure in a single well consists of two low rails (LRs) for primary hydrogel patterning and one high rail (HR) to form a channel for secondary fluid patterning after hydrogel cross-linking. (c) Procedure of using the device. Once a hydrogel pre-solution is filled and withdrawn through an injection hole, the solution remains only underneath LRs. When the hydrogel is cross-linked, a microfluidic channel is formed where another fluid can be loaded.