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. 2019 May 28;10:579. doi: 10.3389/fphar.2019.00579

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Copyright © 2019 Chen, Zhang, Chen, Ran, Yu, Liu, Fu, Song, Tang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PB-MSCs-released IL1RA was involved in the M1-type switch into M2 type. (A) The typical results of M1 (i.e., iNOS and TNFα) or M2 (i.e., CD206 and Arg-1) type by flow cytometry in M1 macrophages treated with condition medium (CM) from TNFα-stimulated PB-MSCs (^TNFαCM) with or without the presence of a neutralizing anti-IL1RA antibody for 3 days. (B–E) Quantitative analysis of results in A showed that CM promoted the polarization of the M1 type toward M2 type, which could be almost completely abolished by the anti-IL1RA antibody. n = 5, ^#p < 0.05, vs. CM, ^&p < 0.01, vs. ^TNFαCM.