Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 28;10:579. doi: 10.3389/fphar.2019.00579

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Chen, Zhang, Chen, Ran, Yu, Liu, Fu, Song, Tang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic diagram of the interaction between PB-MSCs and macrophages. Quiescent MSCs inhabit the hematopoietic niche, which is mainly composed of osteoblasts and the vascular network. In the process of mobilization by G-CSF combined with AMD3100, BM-MSCs detached from the niche because of block of SDF-1α/CXCR4 axis by AMD3100 to cut off SDF-1α binding into CXCR4, and G-CSF to reduce SDF-1α levels in the niche (Petit et al., 2002; Tang et al., 2011; Hoggatt et al., 2018). Mobilized BM-MSCs enter peripheral blood, functioning as PB-MSCs. PB-MSCs contributed to the polarization of M1 toward M2 type in the inflammatory sites though IL1RA, which were associated with NF-κB signaling pathway.