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. 2019 May 28;10:573. doi: 10.3389/fphar.2019.00573

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Copyright © 2019 Leu, Chen and Guh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic figure for PA-F4-mediated inhibitory effect on the activation of NLRP3 inflammasome. PA-F4 inhibited LPS priming step through the block of p65 NF-κB activation. It also inhibited ATP-induced signaling pathways in LPS-primed cells including the inhibition of the interaction between NLRP3 and ASC, K⁺ efflux reaction, and the release reaction of caspase-1, IL-1β, and IL-18. Taken together, the data suggest that PA-F4 shows an inhibitory activity on blocking the activation of NLRP3 inflammasome.