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. 2019 May 28;11:112. doi: 10.3389/fnagi.2019.00112

Figure 2.

Figure 2

Hyper-phosphorylated tau containing cells and fibers following unilateral intra-hippocampal injection (A–C) and unilateral inoculation into the corpus callosum (D–H) of sarkosyl-insoluble fractions from AD cases into WT mice at the age of 10 and 12 months, respectively, and killed 6 months later. (A,B) tau-containing neurons and rare glial cells in the hippocampus; (C) tau-containing glial cells and threads in the fimbria. Tau- containing glial cells and threads in the ipsilateral (D), middle region (E) and contralateral corpus callosum (F). Paraffin sections immunostained with AT8 antibody and slightly counterstained with hematoxylin; (A–F), bar = 25 μm. (G,H) Double-labeling immunofluorescence to GFAP (green) and AT8 (red) (G), and to Olig2 (green) and AT8 (red) in the corpus callosum of WT mice inoculated with sarkosyl-insoluble fractions from AD at the age of 12 months and killed at the age of 18 months after unilateral inoculation in the corpus callosum. No tau deposits are seen in astrocytes (G), but phospho-tau is present in oligodendrocytes (arrows). Paraffin sections, nuclei stained with DRAQ5™ (blue); bar = 20 μm.