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. 2019 May 28;11:112. doi: 10.3389/fnagi.2019.00112

Figure 7.

Figure 7

(A–C) Double-labeling immunofluorescence to phosphorylated p38 (p38-P: Thr180-182) (green) and AT8 (red) in the corpus callosum of WT mice inoculated unilaterally with sarkosyl-insoluble fractions from ARTAG at the age of 12 months and killed at the age of 19 months. Phospho-p38 kinase (p38-P) co-localizes with tau deposits (arrows) in oligodendrocytes in the ipsilateral corpus callosum (A), middle region (B), and contralateral corpus callosum (C). (D) Double-labeling immunofluorescence to phospho-ERK 1/2 (Thr202/Tyr204) (green) and phospho-tau Thr181 (red) in the corpus callosum of WT mice inoculated with sarkosyl-insoluble fractions from GGT at the age of 12 months and killed at the age of 19 months. Phospho-ERK 1/2 co-localizes with tau deposits (arrows) in oligodendrocytes. (E–G) Double-labeling immunofluorescence to p38-P and AT8 (merge) in oligodendroglial cells of the corpus callosum of WT mice inoculated unilaterally with sarkosyl-insoluble fractions from PART (E), PSP (F), or PiD (G) at the age of 10–12 months and killed 6 months later. Paraffin sections, nuclei stained with DRAQ5™ (blue), (A,B), bar = 5 μm; (C) bar = 10 μm; (D) bar = 20 μm; (E–G), bar in (G) = 10 μm.