Table 1.
Respiratory mechanics and arterial blood gases.
| C | ELA | |||
|---|---|---|---|---|
| SAL | LPS | SAL | LPS | |
| Spontaneous breathing | ||||
| V T (ml/kg) | 6.0 ± 0.1 | 5.8 ± 0.3 | 5.7 ± 0.4 | 5.8 ± 0.4 |
| RR (breaths/min) | 41 ± 4 | 44 ± 4 | 46 ± 7 | 50 ± 7 |
| Ti (s) | 0.55 ± 0.07 | 0.47 ± 0.06 | 0.33 ± 0.08 * | 0.31 ± 0.08 |
| Te (s) | 0.84 ± 0.06 | 0.86 ± 0.05 | 1.10 ± 0.11 * | 0.92 ± 0.16 |
| Ti/Ttot (s) | 0.38 ± 0.03 | 0.35 ± 0.02 | 0.26 ± 0.05 * | 0.28 ± 0.05 |
| E L (cmH2O/ml) | 3.2 ± 0.2 | 4.3 ± 0.5 * | 4.9 ± 0.6 * | 6.8 ± 0.4 # |
| PTP/min (cmH2O.s/min) | 11.5 ± 2.2 | 12.8 ± 1.3 | 19.4 ± 2.8 * | 27.1 ± 5.5 # |
| P 0.1 (cmH2O) | −1.04 ± 0.44 | −1.07 ± 0.57 | −1.93 ± 0.53 | −2.33 ± 0.67 |
| Arterial blood gases | ||||
| PHa | 7.39 ± 0.06 | 7.38 ± 0.06 | 7.36 ± 0.08 | 7.33 ± 0.06 |
| PaCO2 (mmHg) | 38 ± 3 | 40 ± 4 | 42 ± 5 | 44 ± 5 |
| PaO2/FiO2 (mmHg) | 428 ± 24 | 295 ± 48 * | 349 ± 41 | 272 ± 59 # |
| HCO3 (mmol/L) | 22 ± 1 | 21 ± 1 | 24 ± 1 | 24 ± 2 |
VT, tidal volume; RR, respiratory rate; Ti, inspiratory time; Te, expiratory time; Ti/Ttot, inspiratory time divided by total respiratory cycle time; EL, dynamic lung elastance; PTP/min pressure–time product per minute; P0.1 esophageal pressure generated 100 ms after onset of inspiratory effort; pHa, arterial pH; PaCO2, arterial partial pressure of carbon dioxide; PaO2/FiO2, arterial partial pressure of oxygen divided by fraction of inspired oxygen (0.21); HCO3, bicarbonate. C, control; ELA, animals treated with intratracheal instillations of elastase; SAL, saline; LPS, E. coli lipopolysaccharide. Values are means ± SD of six animals in each group.
Significantly different from C-SAL group (p < 0.05).
Significantly different from ELA-SAL group (p < 0.05).