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. 2019 Jun 3;9:8181. doi: 10.1038/s41598-019-44417-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Voxel-level tissue survival as a function of collateral perfusion. In Peri-Core voxels greater Indirect CBF at presentation significantly increases the probability of tissue survival at one week. Each bar represents the fraction of voxels, across all patients, that survive within each given range of Indirect CBF. The asterisk (*) represents the significant difference in survival fraction for tissue receiving less than 25 ml/100 g/min of Indirect CBF compared to that receiving more than this value (p < 0.0001).