Table III.
Statistical analysis of mRNA expression of genes in diffuse/poorly cohesive relative to intestinal-subtype gastric carcinoma.
| A, Growth factors and receptors (n=10) | |||
|---|---|---|---|
| Genes | Diffuse/poorly cohesive adenocarcinoma (n=13)b | Intestinal carcinoma (n=16)b | P-valuea |
| IGF1 | 7.37 (0.97–12.75) | 1.14 (0.1–10.09) | 0.0012 |
| IGF2 | 2.26 (0.80–19.16) | 1.51 (0.18–6.18) | 0.51 (NS) |
| IGF1R | 1.10 (0.63–1.55) | 0.60 (0.39–9.33) | 0.044 |
| IGF2R | 1.43 (0.85–1.65) | 1.45 (0.81–2.63) | 0.55 (NS) |
| IRS1 | 1.50 (0.91–2.71) | 1.11 (0.56–18) | 0.079 (NS) |
| IRS2 | 1,13 (0,52–4,44) | 0.89 (0.15–1.77) | 0.10 (NS) |
| FGF7 | 2.16 (1.10–3.45) | 0.70 (0.07–2.44) | 0.00011 |
| FGFR1 | 1.94 (0.96–3.53) | 1.04 (0.31–2.68) | 0.048 |
| ERRB2 | 1.62 (0.87–2.74) | 2.20 (1.05–34.55) | 0.066 (NS) |
| ERRB3 | 0.91 (0.51–2.55) | 1.54 (0.59–3.49) | 0.066 (NS) |
| B, EMT and migration (n=10) | |||
| Genes | Diffuse/poorly cohesive adenocarcinoma (n=13)b | Intestinal carcinoma (n=16)b | P-valuea |
| VIM | 1.62 (0.88–2.37) | 1.35 (0.48–2.79) | 0.072 (NS) |
| CDH1 | 0.78 (0.01–1.06) | 1.01 (0.29–1.63) | 0.014 |
| SNAI1 | 2.39 (0.90–4.92) | 3.21 (0.52–11.62) | 0.26 (NS) |
| SLUG/SNAI2 | 3.02 (1.15–4.06) | 2.56 (1.0–10.50) | 1.00 (NS) |
| TWIST2 | 2.30 (0.62–3.29) | 1.46 (0.12–3.23) | 0.087 (NS) |
| TGFB1 | 2.05 (1.47–4.27) | 2.17 (1.05–6.51) | 1.00 (NS) |
| RUNX3 | 1.77 (0.00–4.91) | 1.66 (0.00–3.98) | 0.44 (NS) |
| ZEB2 | 1.70 (0.84–2.97) | 0.82 (0.27–1.60) | 0.000079 |
| CXCR4 | 3.14 (1.52–7.30) | 1.71 (0.5–7.16) | 0.035 |
| CXCL12 | 1.05 (0.30–3.19) | 0.43 (0.08–1.86) | 0.013 |
| C, Cell proliferation and migration (n=7) | |||
| Genes | Diffuse/poorly cohesive adenocarcinoma (n=13)b | Intestinal carcinoma (n=16)b | P-valuea |
| MMP2 | 3.21 (1.47–6.15) | 2.99 (0.46–7.95) | 0.48 (NS) |
| MMP9 | 2.01 (0.92–4.13) | 5.25 (0.80–19.27) | 0.018 |
| SPP1 osteopontin | 4.12 (1.75–89.35 | 14.51 (1.06–119.54) | 0.25 (NS) |
| CD44 | 1.73 (1.02–2.81) | 1.42 (0.75–2.55) | 0.20 (NS) |
| RHOB | 0.52 (0.32–1.23) | 0.34 (0.12–0.93) | 0.018 |
| RHOA | 8.65 (0.03–20.39) | 2.79 (0.59–23.08) | 0.16 (NS) |
| MKI67 | 3.76 (1.34–10.83) | 8.48 (1.83–17.67) | 0.0057 |
| D, Angiogenesis (n=6) | |||
| Genes | Diffuse/poorly cohesive adenocarcinoma (n=13)b | Intestinal carcinoma (n=16)b | P-valuea |
| VEGFA 165 | 0.86 (0.58–2.09) | 1.02 (0.69–4.07) | 0.15 (NS) |
| VEGFA 189 | 0.67 (0.42–1.00) | 0.70 (0.30–2.04) | 0.46 (NS) |
| FLT1 | 1.08 (0.62–2.07) | 1.06 (0.43–1.60) | 0.90 (NS) |
| KDR | 1.11 (0.67–1.47) | 1.12 (0.57–1.78) | 0.90 (NS) |
| VEGFC | 1.38 (0.86–2.60) | 1.63 (0.51–3.34) | 0.90 (NS) |
| NRP1 | 1.94 (1.21–3.27) | 1.71 (0.74–4.00) | 0.33 (NS) |
a
Mann Whitney's U test.
b
Median (range) of gene mRNA expression levels. NS, not significant.