Table IV.
A, Growth factors and receptors (n=10) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
IGF1 | FGF7 | CDH1 | ZEB2 | CXCR4 | ||||||
Genes | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea |
IGF1 | 1.0 | <0.0001 | 0.670 | 0.012 | 0.533 | 0.061 | 0.797 | 0.0011 | −0.049 | 0.87 |
IGF2 | 0.335 | 0.26 | 0.599 | 0.031 | −0.170 | 0.58 | 0.528 | 0.064 | 0.467 | 0.11 |
IGF1R | 0.412 | 0.16 | 0.440 | 0.13 | 0.418 | 0.16 | 0.445 | 0.13 | 0.401 | 0.17 |
IGF2R | 0.434 | 0.14 | 0.088 | 0.78 | 0.901 | <0.0001 | 0.275 | 0.36 | 0.209 | 0.49 |
IRS1 | 0.407 | 0.17 | 0.539 | 0.058 | 0.407 | 0.17 | 0.385 | 0.19 | 0.363 | 0.22 |
IRS2 | 0.528 | 0.064 | 0.571 | 0.041 | 0.577 | 0.039 | 0.357 | 0.23 | 0.269 | 0.37 |
FGF7 | 0.670 | 0.012 | 1.0 | <0.0001 | 0.165 | 0.59 | 0.819 | 0.0006 | 0.126 | 0.68 |
FGFR1 | 0.610 | 0.027 | 0.786 | 0.0015 | −0.170 | 0.58 | 0.775 | 0.0019 | −0.313 | 0.30 |
ERBB2 | 0.429 | 0.14 | 0.368 | 0.22 | 0.676 | 0.011 | 0.462 | 0.11 | 0.198 | 0.52 |
ERBB3 | 0.434 | 0.14 | 0.500 | 0.082 | 0.478 | 0.099 | 0.522 | 0.067 | 0.396 | 0.18 |
B, EMT and migration (n=11) | ||||||||||
IGF1 | FGF7 | CDH1 | ZEB2 | CXCR4 | ||||||
Genes | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea |
VIM | 0.648 | 0.017 | 0.709 | 0.0067 | 0.341 | 0.25 | 0.764 | 0.0024 | 0.038 | 0.90 |
CDH1 | 0.533 | 0.061 | 0.165 | 0.59 | 1.0 | <0.0001 | 0.291 | 0.33 | 0.104 | 0.73 |
SNAI1 | 0.093 | 0.76 | −0.110 | 0.72 | 0.330 | 0.27 | −0.357 | 0.23 | 0.192 | 0.53 |
SNAI2 | 0.709 | 0.0067 | 0.670 | 0.012 | 0.423 | 0.15 | 0.830 | 0.0005 | 0.357 | 0.23 |
TWIST2 | 0.736 | 0.0041 | 0.830 | 0.0005 | −0.029 | 0.91 | 0.874 | <0.0001 | −0.302 | 0.32 |
TGFB1 | 0.302 | 0.32 | 0.528 | 0.064 | 0.104 | 0.73 | 0.555 | 0.049 | 0.374 | 0.21 |
RUNX3 | 0.341 | 0.25 | 0.643 | 0.018 | −0.132 | 0.67 | 0.560 | 0.046 | 0.396 | 0.18 |
ZEB2 | 0.797 | 0.0011 | 0.819 | 0.0006 | 0.291 | 0.33 | 1.0 | <0.0001 | 0.022 | 0.94 |
SIP1 | 0.149 | 0.63 | −0.182 | 0.55 | 0.234 | 0.44 | 0.080 | 0.80 | −0.374 | 0.21 |
CXCR4 | −0.049 | 0.87 | 0.126 | 0.68 | 0.104 | 0.73 | 0.022 | 0.94 | 1.0 | <0.0001 |
CXCL12 | 0.533 | 0.061 | 0.610 | 0.027 | −0.154 | 0.62 | 0.780 | 0.0017 | −0.352 | 0.24 |
C, Cell proliferation and migration (n=7) | ||||||||||
IGF1 | FGF7 | CDH1 | ZEB2 | CXCR4 | ||||||
Genes | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea |
MMP2 | 0.819 | 0.0006 | 0.720 | 0.0055 | 0.269 | 0.37 | 0.692 | 0.0087 | 0.055 | 0.86 |
MMP9 | 0.121 | 0.69 | 0.489 | 0.090 | 0.049 | 0.87 | 0.423 | 0.15 | 0.484 | 0.094 |
SPP1 | 0.071 | 0.82 | 0.313 | 0.30 | 0.137 | 0.65 | 0.022 | 0.94 | 0.489 | 0.090 |
CD44 | 0.571 | 0.041 | 0.225 | 0.46 | 0.170 | 0.58 | 0.264 | 0.38 | 0.016 | 0.96 |
RHOB | 0.203 | 0.51 | 0.121 | 0.69 | 0.016 | 0.96 | −0.132 | 0.67 | −0.203 | 0.51 |
RHOA | 0.335 | 0.26 | 0.038 | 0.90 | 0.643 | 0.018 | 0.137 | 0.65 | 0.214 | 0.48 |
MKI67 | 0.308 | 0.31 | 0.071 | 0.82 | 0.703 | 0.0073 | 0.038 | 0.90 | 0.005 | 0.99 |
D, Angiogenesis (n=6) | ||||||||||
IGF1 | FGF7 | CDH1 | ZEB2 | CXCR4 | ||||||
Genes | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea | r | P-valuea |
VEGF165 | 0.335 | 0.26 | 0.434 | 0.14 | 0.478 | 0.099 | 0.071 | 0.82 | 0.187 | 0.54 |
VEGF189 | 0.187 | 0.54 | 0.335 | 0.26 | 0.330 | 0.27 | 0.115 | 0.71 | 0.500 | 0.082 |
FLT1 | 0.418 | 0.16 | 0.412 | 0.16 | 0.352 | 0.24 | 0.104 | 0.73 | 0.214 | 0.48 |
KDR | −0.330 | 0.27 | −0.121 | 0.69 | −0.071 | 0.82 | −0.286 | 0.34 | 0.313 | 0.30 |
VEGFC | 0.231 | 0.45 | 0.473 | 0.10 | 0.093 | 0.76 | 0.236 | 0.44 | −0.044 | 0.89 |
NRP1 | 0.681 | 0.010 | 0.802 | 0.0010 | 0.247 | 0.42 | 0.725 | 0.0050 | 0.044 | 0.89 |
Spearman rank test.