Figure 1.
Cell proliferation evaluated by MTT assay and flow cytometry. (A) It was observed that iodine at lower concentrations (1.0×10−4, 1.0×10−5, 1.0×10−6, 1.0×10−7 and 1.0×10−8 mol/l) contributed to the proliferation of BCPAP cells, while iodine of a higher concentration (1.0×10−3 mol/l) had a negative effect. Cells treated with iodine at 1.0×10−6 mol/l exhibited the most pronounced changes. (B) BCPAP cell apoptosis was analysed by flow cytometry with different concentrations of iodine. BCPAP cell apoptosis, when incubated with lower concentrations of iodine (1.0×10−4, 1.0×10−5, 1.0×10−6, 1.0×10−7 and 1.0×10−8 mol/l) was significantly inhibited. Among these, the highest inhibitory effect was observed with 1.0×10−6 mol/l iodine. A higher concentration of iodine (1.0×10−3 mol/l) appeared to promote cell apoptosis. *P<0.05 and **P<0.01 vs. the control group. OD, optical density.