Table 2.

Selective rodent studies supporting the role of DNA methylation in predator stress model.

Reference	Candidate gene	Epigenetic changes	Sample size	Generation study carried out through
Chertkow-Deutsher et al. (2010)	Dlgap2	Higher Dlgap2 methylation and reduced mRNA expression in predator odor exposed rat’s hippocampus.	Not mentioned	F0
Bowen et al. (2014)	Avp	Predatory stress was associated with decreased Avp promoter methylation in the medial amygdala	48	F0
St-Cyr and McGowan (2015)	Bdnf	Female offspring of mice exposed to predator odor during pregnancy had decreased Bdnf transcript abundance positively correlated with a concomitant decrease in methylation of Bdnf exon IV in the hippocampus	42	F0, F1(Intergeneration)
St-Cyr et al. (2017)	Nr3c1, Fkfbp5	Female offspring from prenatal predator odor-exposed dams showed increased transcript abundance of both the glucocorticoid receptor gene (Nr3c1; on the day of birth) and Fkfbp5 (in adulthood) in the amygdala	24	F0, F1(Intergeneration)

Abbreviations: amplification of inter-methylated sites (Aims), arginine vasopressin (Avp), brain-derived neurotrophic factor (Bdnf), disks large-associated protein 2 (Dlgap2), FK506 binding protein 5 (Fkbp5), nuclear receptor subfamily 3 group C member 1 gene (Nr3c1, glucocorticoid receptor gene).