Table 3. Treatment Response Rates to TCIs for Vitiligo.
| Condition | Treatment Response Rate, % (95% CI) | Included Studies | ||
|---|---|---|---|---|
| ≥75% Repigmentation | ≥50% Repigmentation | ≥25% Repigmentation | ||
| TCI Monotherapy | ||||
| Total | 18.1 (13.2-23.1) | 38.5 (28.2-48.8) | 55.0 (42.2-67.8) | 653 Patients in 25 studies (7, 8, 22-43, 64) |
| Children | 31.7 (6.7-56.8) | 47.3 (19.0-75.7) | 66.4 (43.2-89.7) | 177 Patients in 6 studies (7, 28, 32, 35, 41, 44) |
| Face and neck | 35.4 (24.9-46.0) | 57.5 (44.4-70.7) | 73.1 (32.6-83.5) | 392 Patients in 18 studies (8, 22, 26, 29, 34, 36, 38, 44-54) |
| Trunk and extremities | 2.3 (0.3-4.3) | 10.6 (5.3-15.8) | 34.2 (13.9-54.6) | 174 Patients in 9 studies (8, 26, 29, 38, 44, 47, 52-54) |
| Hands and feet | 0.00 (NA) | 1.71 (0.00-4.6) | 15.1 (6.7-23.4) | 52 Patients in 4 studies (26, 29, 47, 52) |
| TCI Plus Phototherapy | ||||
| Total | 47.5 (30.6-64.4) | 72.9 (57.6-88.2) | 89.5 (81.1-97.9) | 533 Patients in 11 studies (30, 36, 55-62, 65) |
| Face and neck | 55.2 (24.6-85.9) | 81.5 (10.3-92.7) | 93.7 (87.6-99.8) | 129 Patients in 5 studies (36, 56, 60, 62, 63) |
| Trunk and extremities | 16.1 (10.2-22.0) | 44.9 (30.3-59.5) | 85.3 (79.8-90.7) | 161 Patients in 3 studies (56, 62, 63) |
Abbreviations: NA, not available; TCI, topical calcineurin inhibitor.