Figure 2. Individual Changes in 5-HT_1B Receptor Binding.

5-HT_1B receptor binding decreased across 7 pain-modulating regions (dorsolateral and ventrolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, sensorimotor cortex, and insula and amygdala) after sumatriptan administration (mean [SD] binding potential, 1.20 [0.20] vs 1.02 [0.22]; P = .001). During migraine attacks, binding was decreased compared with a migraine-free day (mean [SD] binding potential, 1.36 [0.22] vs 1.20 [0.20]; P = .02). Binding potential is the mean volume-weighted nondisplaceable binding potential.