Table 3. Comparison of Overall Change in Scores on Tinnitus Questionnaire, Tinnitus Functional Index, and Tinnitus Handicap Inventory and Subscale Scores in Partial TRT and TRT Groups With Overall Change in SoC Group.
| Scale | Estimate (95% CI)a | |
|---|---|---|
| Partial TRT | TRT | |
| Tinnitus Questionnaire | ||
| Total score | −2.81 (−8.27 to 2.65) | −2.35 (−8.77 to 4.07) |
| Emotional distress | −0.60 (−3.16 to 1.96) | −0.39 (−3.08 to 2.29) |
| Intrusiveness | −0.12 (−1.14 to 0.90) | −0.36 (−1.38 to 0.67) |
| Auditory perceptual difficulties | −0.36 (−1.35 to 0.64) | 0.38 (−1.37 to 0.61) |
| Sleep disturbance | −0.87 (−1.56 to −0.17) | −0.10 (−0.74 to 0.53) |
| Somatic complaint | −0.20 (−0.86 to 0.46) | −0.07 (−0.83 to 0.69) |
| Tinnitus Functional Index | ||
| Total score | 2.74 (−2.21 to 7.70) | −0.14 (−5.30 to 5.02) |
| Emotional distress | −3.02 (−9.43 to 3.40) | −0.13 (−6.78 to 6.52) |
| Intrusiveness | −0.91 (−6.75 to 4.93) | −3.19 (−9.27 to 2.88) |
| Reduced sense of control | 3.29 (−3.00 to 9.54) | 3.12 (−3.44 to 9.68) |
| Cognitive interference | 0.94 (−5.44 to 7.32) | 1.41 (−5.20 to 8.01) |
| Sleep disturbance | −13.70 (−22.02 to −5.38) | −3.53 (−12.30 to 5.23) |
| Auditory difficulties | −0.23 (−7.72 to 7.26) | 3.71 (−3.96 to 11.38) |
| Relaxation interference | −4.46 (−11.48 to 2.55) | −1.85 (−9.07 to 5.38) |
| Reduced quality of life | −3.52 (−9.26 to 2.22) | 1.24 (−4.67 to 7.14) |
| Tinnitus Handicap Inventory | ||
| Total score | −4.51 (−9.15 to 0.13) | −0.05 (−4.90 to 4.81) |
| Functional subscale | −2.10 (−5.21 to −0.41) | −0.82 (−3.30 to 1.66) |
| Emotional subscale | −1.04 (−2.83 to 0.75) | 0.34 (−1.54 to 2.23) |
| Catastrophic subscale | −0.62 (−1.75 to 0.52) | 0.61 (−0.55 to 1.77) |
Abbreviations: SoC, standard of care; TRT, tinnitus retraining therapy.
a
Values representing mean difference in change in score over time compared with that of the SoC group were estimated using generalized estimating equations models adjusted for visit; clinical center; age group; sex; and baseline scores on the State-Trait Anxiety Inventory and Positive and Negative Affect Schedule, with multiple imputation for missing values.