. 2019 May 23;137(8):867–876. doi: 10.1001/jamaophthalmol.2019.1318

Table 2. Univariate Correlation Between Clinical and Demographic Variables and Geographic Atrophy Growth Rates.

	AREDS		FAM/DSGA		GATE		Combined
	Slope (95% CI)	P Value	Slope (95% CI)	P Value	Slope (95% CI)	P Value	Slope (95% CI)^a	P Value
Baseline square root geographic atrophy area, per mm	−0.082 (−0.156 to −0.008)	.03	0.006 (−0.137 to 0.148)	.93	0.001 (−0.114 to 0.115)	.99	−0.047 (−0.104 to 0.010)	.10
Age, per y	−0.003 (−0.023 to 0.017)	.77	0.012 (−0.009 to 0.034)	.27	0.002 (−0.011 to 0.014)	.75	−1.574 (−3.660 to 0.512)	.14
Female	0.117 (−0.095 to 0.328)	.28	0.062 (−0.266 to 0.389)	.71	0.081 (−0.115 to 0.276)	.42	0.091 (−0.04 to 0.223)	.19
First principal component^b	−4.046 (−8.735 to 0.643)	.09	−2.225 (−14.46 to 10.01)	.72	−0.915 (−3.296 to 1.466)	.45	0.003 (−0.007 to 0.012)	.54
Second principal component^b	1.749 (−8.165 to 11.66)	.73	2.283 (−1.245 to 5.811)	.20	−0.911 (−5.240 to 3.417)	.68	1.062 (−1.566 to 3.690)	.43
Geographic atrophy in both eyes	0.204 (−0.009 to 0.417)	.06	0.189 (−0.123 to 0.501)	.24	0.281 (0.074 to 0.487)	.008	0.233 (0.100 to 0.367)	.001
Follow-up time within study period, per y	−0.035 (−0.068 to −0.002)	.04	−0.070 (−0.133 to −0.006)	.03	−0.157 (−0.356 to 0.043)	.12	−0.045 (−0.074 to −0.016)	.002
Geographic atrophy lesions, per lesion	0.277 (0.192 to 0.363)	6 × 10⁻¹⁰	0.161 (0.095 to 0.227)	3 × 10⁻⁰⁶	0.134 (0.095 to 0.173)	6 × 10⁻¹¹	0.159 (0.128 to 0.191)	2 × 10⁻²³
Age-related macular degeneration genetic risk score,^c per allele	0.025 (0.006 to 0.044)	.02	−0.015 (−0.043 to 0.013)	.21	0.016 (−0.003 to 0.034)	.09	0.014 (0.002 to 0.027)	.03

Abbreviations: AREDS, Age-Related Eye Disease Study; DSGA, Directional Spread in Geographic Atrophy; FAM, Fundus Autofluorescence Imaging in Age-Related Macular Degeneration; GATE, Geographic Atrophy Treatment Evaluation.

^{^a}

Adjusted for study.

^{^b}

Principal components calculated from the genotypes.

^{^c}

Effect size (log odds) weighted age-related macular degeneration genetic risk score calculated from 37 condition-associated, well-imputed variants, normalized by the mean log odds of all 37 variants.⁸