Table 2. Multivariable Cox Proportional Hazards Regression Modeling for Overall Survival Among 357 Unmatched Patients.
| Characteristic | Hazard Ratio (95% CI)a | P Value |
|---|---|---|
| Age, y | ||
| <65 | 1 [Reference] | .004 |
| 65-75 | 1.41 (0.88-2.27) | .15 |
| >75 | 2.67 (1.58-4.51) | <.001 |
| Race/ethnicity | ||
| White | 1 [Reference] | <.001 |
| Black | 3.93 (1.95-7.93) | <.001 |
| Asian or other | 0.30 (0.04-2.28) | .25 |
| T classification | ||
| T1-2 | 1 [Reference] | NA |
| T3-4 | 2.48 (1.60-3.84) | <.001 |
| N classification | ||
| Node-negative | 1 [Reference] | NA |
| Node-positive | 2.52 (1.54-4.14) | <.001 |
| Grade | ||
| Well differentiated | 1 [Reference] | .24 |
| Moderately differentiated | NA | .60 |
| Poorly differentiated or undifferentiated | NA | .10 |
| Lymphovascular invasion | ||
| Absent | 1 [Reference] | NA |
| Present | NA | .53 |
| Perineural invasion | ||
| Absent | 1 [Reference] | NA |
| Present | NA | .05 |
| Resection margin | ||
| Margin negative (R0) | 1 [Reference] | NA |
| Margin positive (R1-R2) | NA | .06 |
| Adjuvant therapy | ||
| No | 1 [Reference] | NA |
| Yes | NA | .68 |
Abbreviation: NA, not applicable.
a
Hazard ratios indicate relative hazard for death and were adjusted for all variables included.