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. 2019 Jun 3;11:1758835919853449. doi: 10.1177/1758835919853449

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Schematic representation of tumor-suppressive roles of SOX11 in cancer development.

SOX11 overexpression might be correlated with slower cancer progression. The tumor-suppressive effect of SOX11 has been attributed to its ability to decrease cell proliferation, repress CICs development, and reduce cancer invasion and metastasis.

ATX, autotaxin; CIC, cancer-initiating cell; DCX, doublecortin; HIG-2, hypoxia-inducible protein 2; NGN2, neurogenin 2; NLK, Nemo-like kinase; SOX11, sex-determining region Y-related high-mobility-group box transcription factor 11; TGF-β, transforming growth factor-β.