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. 2018 Feb 12;39(6):1122–1137. doi: 10.1177/0271678X18755661

Figure 3.

Figure 3.

JZL195 elicits CA1 LTD via glutamate receptors. Plots of normalized fEPSP slopes in anesthetized rats (a, b) or mice (d) show that JZL195 injection at 0 min elicits CA1 LTD in animals, which is blocked by pretreatment with ceftriaxone (a), Ro25-6981, ifenprodil (b) or Tat-GluR2 (d). Representative fEPSP traces before (1) and after (2) treatment are shown above each plot. (c) Graphs and immunoblotting (bottom photos) show a decrease in GluR2 at the synaptic surface of CA1 neurons after JZL195 injection. (e) Bar charts summarizing the average percent change of fEPSP slope before (1) and after (2) vehicle or JZL195 injection as depicted in panels a, b and d. All summary graphs show means ± SEMs; n = numbers of animals assessed in each group (a) to (d). *p < 0.01 vs. vehicle (a) and (b) or Tat-GluR2S (d), Bonferronni post-hoc test after one-way ANOVA ((b): F2,8 = 41.090, p < 0.01) or t test (a), (c) and (d).