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Diagrammatic sketch for neuroprotection through astroglial eCB-LTD. An elevation of interstitial eCB flux stimulates astroglial CB1R, suppresses GLT1, increases ambient glutamate, activates postsynaptic NR2B, and induces AMPAR endocytosis, which elicits LTD expression at glutamatergic synapses to trigger neuroprotection.
