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Polymorphism plot to estimate nondisplaceable uptake (VND) in an imaginary region with no specific binding (x-intercept). For 41 different brain regions, the distribution volume (VT) in mixed-affinity binders (MABs) was subtracted from that in high-affinity binders (HABs) and plotted against the distribution volume (VT) of HABs. The extrapolated x-intercept marked with a circle shows that the estimated VND for this population was 1.4 mL · cm−3.
