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. 2017 Dec 5;39(6):1038–1055. doi: 10.1177/0271678X17746132

Figure 1.

Figure 1.

Evaluation of MgSO4 preconditioning protection.(a) Macroscopic brain injury assessment – brains were collected from rat pups preconditioned with (a) vehicle (n = 18) or (b) MgSO4 (n = 17) 24 h prior to HI, collected seven days post HI (p < 0.0001). Brain injury analyses were performed on MAP-2 stained sections (c and d) and MBP-stained sections (e and f) at the level of anterior hippocampus from brains shown in image (a) and (b). (B) Overall summary of macroscopic brain injury score at 6 days–12 h; n = 72/condition (p < 0.0001) (Mann–Whitney U test, Mean ± SEM). (c) Macroscopic brain injury score and measurement of grey (MAP-2) and white (MBP) matter injury at PND 14 after i.p. injection with NaCl (vehicle) or MgSO4 at different time points prior to and post HI, (p < 0.05) (Mann–Whitney U test, Mean ± SEM).