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How Adaptive Randomization Using Minimization Works
| Prognostic factor | Control group | Treatment group |
|---|---|---|
| Site | ||
| Site 1 | 0 | 0 |
| Site 2 | 0 | 1 |
| Sex | ||
| Male | 0 | 1 |
| Female | 0 | 0 |
| Age band | ||
| < 20 | 0 | 0 |
| 20–64 | 0 | 1 |
| ≥ 65 | 0 | 0 |
The score in each factor is 0. The first patient (sex male, 52 yr, from site 2) is allocated to the treatment group through simple randomization. Therefore, site 2, sex male, and the 20–64 years age band in the treatment group receive the score.
