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. 2019 May 27;11(5):450–463. doi: 10.4254/wjh.v11.i5.450

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Molecular mechanisms of cholestasis at the apical hepatocellular membrane. FXR: Farnesoid X receptor; RXR: Retinoid x receptor alpha; ABCB11: ATP binding cassette subfamily B member 11; MYO5B: Myosin VB; RAB11A: Ras-related protein Rab11a; FIC1: Familial intrahepatic cholestasis 1; BSEP: Bile salt export pump; MDR3: Multidrug resistance 3; TJP2: Tight junction protein 2.