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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: J Cyst Fibros. 2017 Oct 31;17(4):503–510. doi: 10.1016/j.jcf.2017.10.003

Table 2.

Estimated Percentage of Predicted FEV1 Intercept and Slope for R117H Patients (n=156) and F508del Patients (n=6,251)*

Parameter Estimate Standard
Error		 P-Value Lower 95%
CI		 Upper 95%
CI
Intercept (ppFEV1)
 R117H 86.58 2.03 <0.001 82.60 90.55
 F508del 76.54 0.26 <0.001 76.04 77.05
 Difference 10.04 2.04 <0.001 6.03 14.04
Slope (ppFEV1/year)
 R117H −0.61 0.21 0.005 −1.03 −0.19
 F508del −2.03 0.02 <0.001 −2.07 −1.98
 Difference 1.42 0.22 <0.001 1.00 1.84
*

Repeated measures model adjusted for correlation within patient. Age group and mutation were fixed effects. All 2-way and 3-way interactions were included. Overall estimates of intercept and slope were calculated by weighting each age group category according to the observed distribution pooled across mutation groups.

CI, confidence interval; ppFEV1, percentage of predicted forced expiratory volume in 1 second.