Table 3.

Age Group Specific Estimated Percentage of Predicted FEV₁ Intercept and Slope for R117H Patients and F508del Patients.^*

Parameter	Estimate	Standard Error	P-value	Lower 95% CI	Upper 95% CI
6-12 year olds (R117H n=36, F508del n=2,398)
Intercept (ppFEV1)
R117H	92.32	3.41	<0.001	85.65	99.00
F508del	88.59	0.42	<0.001	87.77	89.40
Difference	3.74	3.43	0.28	−2.99	10.46
Slope (ppFEV1/year)
R117H	0.73	0.34	0.032	0.06	1.39
F508del	−1.91	0.04	<0.001	−1.98	−1.84
Difference	2.64	0.34	<0.001	1.97	3.31
13-17 year olds (R117H n=17, F508del n=1,447)
Intercept (ppFEV1)
R117H	95.40	4.99	<0.001	85.62	105.18
F508del	78.43	0.53	<0.001	77.38	79.47
Difference	16.97	5.02	<0.001	7.13	26.82
Slope (ppFEV1/year)
R117H	−1.55	0.55	0.005	−2.63	−0.47
F508del	−2.66	0.04	<0.001	−2.74	−2.57
Difference	1.11	0.55	0.046	0.02	2.19
18-24 year olds (R117H n=18, F508del n=1,278)
Intercept (ppFEV1)
R117H	82.23	4.84	<0.001	72.73	91.72
F508del	67.81	0.57	<0.001	66.70	68.93
Difference	14.41	4.88	0.003	4.85	23.97
Slope (ppFEV1/year)
R117H	−1.52	0.53	0.004	−2.56	−0.49
F508del	−2.12	0.05	<0.001	−2.22	−2.02
Difference	0.60	0.53	0.26	−0.45	1.64
≥25 year olds (R117H n=85, F508del n=1,128)
Intercept (ppFEV1)
R117H	69.05	2.22	<0.001	64.69	73.41
F508del	59.42	0.61	<0.001	58.23	60.62
Difference	9.63	2.31	<0.001	5.11	14.15
Slope (ppFEV1/year)
R117H	−1.17	0.23	<0.001	−1.62	−0.71
F508del	−1.40	0.06	<0.001	−1.51	−1.29
Difference	0.23	0.24	0.33	−0.24	0.70

^*Repeated measures model adjusted for correlation within patients. Age group and mutation were fixed effects. All 2-way and 3-way interactions were included.

CI, confidence interval; ppFEV₁, percentage of predicted forced expiratory volume in 1 second.