Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 24;47(10):4911–4926. doi: 10.1093/nar/gkz292

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — A model of spliceosome assembly (A) in the absence of HDACs, where Clk and other kinases (not shown) phosphorylate SR proteins, enabling them to bind to exonic splicing enhancers (ESEs), triggering a cascade of proteins to form the major spliceosome. (B) In the presence of HDACs, Clks are unable to phosphorylate SR proteins, inhibiting spliceosomal assembly.