Table 3.
Diseases associated with dysregulated RNA splicing and related HDACs
| Disease | Spliced Gene | HDAC |
|---|---|---|
| Familial Dysautonomia | IKBKAP (161) | HDAC6 (162) |
| Spinal Muscular Atrophy | SMN1 (163–165) | Class I (136) |
| Hutchinson-Gilford Progeria Syndrome | LMNA (166) | Class I-II (167) |
| Myotonic Dystrophy | CLCN1 (168) | Class II (169) |
| Dilated Cardiomyopathy | LMNA (170) | Class I (171) |
| Early-onset Parkinson's Disease | PINK1 (172) | HDAC3 (173) |
| Retinitis Pigmentosa | PRPF6 (174) | Class I (175) |
| Myelodysplastic Syndromes | U2AF1 (176,177) | Class I-IV (178) |
| Amyotrophic Lateral Sclerosis | TARDP; FUS (179–181) | HDAC6 (182) |
| Hair Cell Degeneration and Deafness | REST ( 145 ) | HDAC1 & HDAC2 (145) |