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. 2019 Apr 3;47(10):5307–5324. doi: 10.1093/nar/gkz194

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — The G28A mutation favours SLII formation in the absence of miR-122. (A) Normalized SHAPE reactivities of G28A (nts 1–117). Nucleotides 1–5 and 14–19 were omitted due to high background reactivity. Nucleotides with high (≥0.85, red), intermediate (between 0.4 and 0.85, orange), low (between 0.2 and 0.4, blue) and very low (≤0.2, black) SHAPE reactivity are indicated. (B) SHAPE data from (A) superimposed on the predicted lowest free energy structures formed by the first 117 nts of the G28A 5′ UTR (SLII^alt and SLII) and their free energy values (ΔG, kcal/mol). The SHAPE data represents the results of four independent replicates and error bars indicate the standard error of the mean (SEM).