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. 2019 Apr 3;47(10):5307–5324. doi: 10.1093/nar/gkz194

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Model of RISC-HCV IRES–40S interactions. A modeled RISC–IRES–40S complex (top left panel) and detailed views of hAgo2:IRES interactions (other panels). Front and back views of the space-filling representation show a tight fit with shape complementarity between hAgo2 and IRES SLIIa (right panels). hAgo2 Mid, L2 and PIWI domains interact with single- and double-stranded regions of the HCV IRES SLIIa (bottom left). The IRES (cyan), ribosomal RNA (yellow), ribosomal proteins (gray), hAgo2s (pink and blue), and miR-122s (orange) are indicated.