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. 2019 Apr 12;47(10):5420–5428. doi: 10.1093/nar/gkz269

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — The NTD of RspWYL1 harbors non-canonical tandem RHH motifs with a novel helical insertion. (A) NTD contains two RHH motifs. RHH1, RHH2 and the helical insertion are colored blue, cyan and magenta, respectively. (B) Superposition of the RHH regions of NTD and AvtR (gray, PDB: 4VH0). The residues involved in the nucleic acid binding are shown in stick representation. (C) Superposition of the RHH regions of NTD and CopG (gray)-DNA (pink) complex (PDB: 1B01). The residues involved in the nucleic acid binding are shown in stick representation. (D) Isothermal titration calorimetric (ITC) analysis of RspWYL1’s binding capabilities toward various types of nucleic acids. ND: no detectable binding. (E) The double mutant on RHH (R131D/R133D) impairs the ssRNA binding.