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. 2019 Mar 27;47(10):5114–5125. doi: 10.1093/nar/gkz182

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Density of genetic polymorphism around origins: average SNP density in the vicinity of all human SNS peaks (plain lines) for different classes of origins, depending on their association with CGI and/or TSSs. Genome-wide averages are indicated by broken lines. (A) Common variants (DAF > 10%). (B) Rare variants (DAF < 1%). (C, D) Base-specific SNP density (see Materials and Methods section) in the vicinity of all human SNS peaks (plain line). Broken lines: genome-wide average. Dotted line: average base-specific SNP density in all human coding exons. (C) Common A or T to C or G () and C or G to A or T () variants (DAF > 10%). (D) Rare variants (DAF < 1%).

Inline graphic — Density of genetic polymorphism around origins: average SNP density in the vicinity of all human SNS peaks (plain lines) for different classes of origins, depending on their association with CGI and/or TSSs. Genome-wide averages are indicated by broken lines. (A) Common variants (DAF > 10%). (B) Rare variants (DAF < 1%). (C, D) Base-specific SNP density (see Materials and Methods section) in the vicinity of all human SNS peaks (plain line). Broken lines: genome-wide average. Dotted line: average base-specific SNP density in all human coding exons. (C) Common A or T to C or G () and C or G to A or T () variants (DAF > 10%). (D) Rare variants (DAF < 1%).