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. 2019 Mar 27;47(10):5114–5125. doi: 10.1093/nar/gkz182

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Profile of sequence conservation around TSSs and replication origins. (A, B) Human TSSs. Black: TSSs <750 bp away from an origin. Blue: TSSs that are not associated with an origin. The red dotted line presents the number of SNS peaks found around all TSSs (smoothed over 50 bp windows). All TSSs are oriented 5′ → 3′ relative to the transcription unit. (A) TSS associated with a CGI (B) TSS not associated to a CGI. (C) Average PhastCons scores calculated in a 1400 bp region centred on human SNS Peaks, depending on the origin association with TSSs and CGIs. The dashed line presents the genome-wide phastCons score average.