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In vitro wound healing and in vivo skin irritation study. a Migration of HFF1 cells to close the wound area. b The HaCaT cell migration to fill the scratch zone in presence of the three different gels in the cell culture media whereas cell culture medium without gels served as the negative control. c Topical application of the gels for irritation assay on shaved rats, which were observed from day 0 to day 7
