Table 3.
The estimated value of interaction effect between APOE and diagnosis in cortical morphometric features
| Groups | APOE | Estimation | 95%CI | P value | |
|---|---|---|---|---|---|
| Cortex volume | SCD | ε4 + | 397.829 ± 8.076 | 381.848–413.810 | .25 |
| ε4 − | 416.300 ± 4.579 | 407.203–425.398 | |||
| NC | ε4 + | 420.606 ± 8.562 | 403.664–437.548 | ||
| ε4 − | 423.750 ± 4.312 | 415.217–432.283 | |||
| Surface area in right hemisphere | SCD | ε4 + | 742.296 ± 13.860 | 714.871–769.722 | .086 |
| ε4 − | 782.810 ± 7.890 | 767.197–798.423 | |||
| NC | ε4 + | 794.782 ± 14.694 | 765.706–823.857 | ||
| ε4 − | 795.956 ± 7.400 | 781.312–810.600 | |||
| Surface area in left hemisphere | SCD | ε4 + | 741.824 ± 15.268 | 711.613–772.036 | .118 |
| ε4 − | 786.760 ± 8.691 | 769.561–803.959 | |||
| NC | ε4 + | 795.066 ± 16.186 | 763.037–827.096 | ||
| ε4 − | 800.473 ± 8.152 | 784.342–816.605 | |||
| Thickness in right hemisphere | SCD | ε4 + | 2.402 ± 0.020 | 2.362–2.442 | .495 |
| ε4 − | 2.381 ± 0.011 | 2.358–2.404 | |||
| NC | ε4 + | 2.378 ± 0.021 | 2.336–2.421 | ||
| ε4 − | 2.380 ± 0.011 | 2.359–2.401 | |||
| Thickness in left hemisphere | SCD | ε4 + | 2.406 ± 0.021 | 2.365–2.447 | .246 |
| ε4 − | 2.374 ± 0.012 | 2.350–2.397 | |||
| NC | ε4 + | 2.381 ± 0.022 | 2.337–2.425 | ||
| ε4 − | 2.389 ± 0.011 | 2.367–2.411 |
Data is expressed as the means ± SD; 95%CI, 95% confidence interval; covariates include age, gender, and year of education; ε4 + was APOE ε4 carriers while ε4 – was non-carriers