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. 2019 Jun 3;10(6):433. doi: 10.1038/s41419-019-1637-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Hierarchical clustering analysis of 86 lncRNAs that were differentially expressed between PTC samples (tumor) and adjacent normal samples (normal) (>2.0-fold, p < 0.05). b Validation of the expression of 14 lncRNAs in 16 pair samples of PTC and adjacent normal tissues was determined by qRT-PCR. c The expression of the seven most differentially expressed lncRNAs in another 53 pairs of samples was determined by qRT-PCR. d LncRNA n384546 expression in 53 pair samples of PTC and adjacent normal tissues. e LncRNA n384546 expression in another cohort of 48 PTC patients. f Relative expression of lncRNA n384546 in PTC tissues without and with lymph node metastasis. g Relative levels of n384546 in normal thyroid cell Nthy-ori 3-1 and two types of PTC cells, B-CPAP and KTC-1, were determined by qRT-PCR. Error bars indicate the mean ± SEM. Data in (e) represent the mean ± SEM of three separate experiments. *p < 0.05, **p < 0.01 in paired Student’s t test (b–f) and independent Student’s t test (g)