Table 3.
Top ten molecular or biological functional annotations.
| Disease cohort | Categories | Diseases or Functions Annotation | p-Value | Predicted Activation State | Activation z-score | Molecules | # |
|---|---|---|---|---|---|---|---|
| Multibacillary | Cellular Growth and Proliferation | proliferation of cells | 5.32E-04 | Decreased | −2.9 | BASP1,CSNK1G3,CYBB,CYP4F2,FABP5,FGL2,FST,GPNMB,IGF2BP3,JUN,KLF5,LY86,MAGI1,MARCKS,MXD1,MXI1,PDK4,RARRES1,RSPO1,S100A13,S100A8,S100A9,STARD10,TBC1D8,TGM1,TJP1,TNFAIP6,TNFSF13B,TNS3,UCHL1 | 30 |
| proliferation of endothelial cells | 1.52E-02 | Decreased | −2.2 | CYBB,CYP4F2,JUN,S100A8,S100A9 | 5 | ||
| Cellular Movement | invasion of cells | 1.02E-03 | −1.9 | FABP5,FST,IFIT2,IGF2BP3,JUN,MAGI1,MARCKS,PDLIM1,S100A12,S100A8,S100A9,TJP1 | 12 | ||
| Lipid Metabolism | concentration of lipid | 5.47E-04 | Decreased | −2.2 | C1QA,CES1,CYBB,CYP4F2,FABP5,JUN,P2RY13,PDK4,S100A12,S100A8,S100A9,STARD10 | 12 | |
| concentration of fatty acid | 1.04E-02 | Decreased | −2.2 | CES1,CYP4F2,P2RY13,PDK4,STARD10 | 5 | ||
| Organismal Development | angiogenesis | 3.65E-02 | Decreased | −2.9 | C1QA,CYBB,CYP4F2,JUN,KLF5,S100A12,S100A8,S100A9,TJP1 | 9 | |
| Organismal Survival | survival of organism | 7.38E-03 | 1.9 | CYBB,DNAJC5,FGL2,FST,GCA,KLF5,MAGI1,S100A9,TNFSF13B | 9 | ||
| Tissue Morphology | growth of epithelial tissue | 5.25E-03 | Decreased | −2.8 | CYBB,CYP4F2,FST,JUN,KLF5,S100A8,S100A9,TGM1,TNFAIP6 | 9 | |
| quantity of connective tissue | 2.50E-02 | Increased | 2.2 | CES1,FABP5,GPNMB,JUN,MXD1,P2RY13,PDK4 | 7 | ||
| growth of connective tissue | 4.07E-02 | Decreased | −2.4 | FST,JUN,KLF5,S100A9,STARD10,TGM1,TNFSF13B | 7 | ||
| Paucibacillary | Cellular Growth and Proliferation | proliferation of cells | 2.60E-02 | −1.5 | AKR1C3,BPI,CD14,CEBPD,CTNNA1,DCBLD2,DTX1,FABP3,HSPB8,IGF2BP3,ITGB3,KCTD12,LY86,MTA3,MYH11,NAGA,NPPC,PAWR,PDK4,RARRES1,RSPO1,SLC39A12,STARD10,TES,TJP1,TNS3,TRIB2,ZBTB32 | 28 | |
| Cellular Movement | cell movement | 1.82E-02 | −1.0 | CAPG,CD14,CEBPD,CES1,COL11A1,CTNNA1,CXCR6,CXXC5,DCBLD2,DTX1,IGF2BP3,ITGB3,MYH11,PLA2G7,PPIC,RARRES1,TJP1,TNS3,TSPAN7 | 19 | ||
| migration of cells | 4.62E-02 | −1.0 | CAPG,CD14,CES1,COL11A1,CTNNA1,CXXC5,DCBLD2,DTX1,IGF2BP3,ITGB3,MYH11,PLA2G7,PPIC,RARRES1,TJP1,TNS3 | 16 | |||
| Metabolic Disease | glucose metabolism disorder | 1.08E-02 | AKR1C3,BPI,CAPG,CEBPD,CLIC5,COL11A1,CXCR6,FABP3,ITGB3,LY86,MYH11,PARD3B,PLD4 | 13 | |||
| Endocrine System Disorders | diabetes mellitus | 4.72E-03 | AKR1C3,BPI,CAPG,CEBPD,CLIC5,COL11A1,CXCR6,ITGB3,LY86,MYH11,PARD3B,PLD4 | 12 | |||
| Tissue Morphology | morphology of connective tissue cells | 3.72E-03 | CEBPD,CES1,CXXC5,DCBLD2,ITGB3,PDK4 | 6 | |||
| Infectious Diseases | Bacterial Infections | 1.73E-02 | −0.2 | BPI,CAPG,CD14,FCN1,LY86,PLA2G7 | 6 | ||
| Cellular Development | differentiation of hematopoietic progenitor cells | 1.90E-02 | CEBPD,DCBLD2,DTX1,MYH11,PLD4 | 5 | |||
| Molecular Transport | concentration of D-glucose | 2.84E-02 | 0.0 | CES1,FABP3,ITGB3,NPPC,PDK4 | 5 | ||
| Lipid Metabolism | transport of lipid | 2.94E-02 | −0.1 | CD14,CES1,FABP3,ITGB3 | 4 | ||
| Resilient | Cellular Growth and Proliferation | proliferation of cells | 5.64E-05 | Decreased | −2.0 | A2M,ACSL6,CSNK1G3,CYBB,EPB41L3,FABP3,GPNMB,HNF4A,KLF5,MAP2,NNAT,PAWR,PTGS2,RSPO1,S100A9,SLC39A12,STARD10,THBS1,TIMP2,TJP1,TNFSF13B,TNS3,VCAN | 23 |
| proliferation of smooth muscle cells | 9.92E-03 | −2.0 | KLF5,PTGS2,THBS1,VCAN | 4 | |||
| Cellular Movement | migration of cells | 9.23E-04 | −1.9 | A2M,CYBB,GPNMB,KLF5,MAP2,OLR1,PTGS2,S100A9,THBS1,TIMP2,TJP1,TNFSF13B,TNS3,VCAN | 14 | ||
| cell movement of leukocytes | 8.75E-03 | −1.8 | CYBB,PTGS2,S100A9,THBS1,TIMP2,TNFSF13B,VCAN | 7 | |||
| cell movement of smooth muscle cells | 1.52E-03 | −1.9 | A2M,PTGS2,THBS1,VCAN | 4 | |||
| cell movement of macrophages | 8.26E-03 | −1.9 | CYBB,PTGS2,THBS1,VCAN | 4 | |||
| Lipid Metabolism | concentration of lipid | 3.52E-03 | −1.9 | CYBB,FABP3,HNF4A,OLR1,P2RY13,PTGS2,S100A9,STARD10 | 8 | ||
| concentration of cholesterol | 1.58E-04 | −1.7 | CYBB,HNF4A,OLR1,P2RY13,PTGS2,STARD10 | 6 | |||
| Molecular Transport | secretion of molecule | 5.47E-03 | Decreased | −2.2 | A2M,OLR1,PTGS2,RSPO1,S100A9,THBS1 | 6 | |
| Organismal Survival | organismal death | 1.72E-03 | 1.9 | A2M,CYBB,ELAVL3,EPB41L3,FABP3,GPNMB,HNF4A,KLF5,MAP2,PTGS2,RSPO1,S100A9,THBS1,TIMP2,TNFSF13B,VCAN | 16 |